神经轴突生长抑制因子受体(NgR)是髓鞘相关抑制因子Nogo-A、髓鞘相关糖蛋白(MAG)和少突胶质细胞髓鞘糖蛋白(OMgp)的共同作用途径。NgR在胶质瘤细胞黏附迁移、凋亡、神经干细胞分化及血管再生重塑等方面发挥着重要作用,有望成为针对神经胶质瘤进行分子靶向治疗的关键分子。
Nogo-66 receptor(NgR) is the common way for three myelin-associated inhibitors Nogo-A, myelin associated glycoprotein(MAG) and oligodendrocyte-myelin glycoprotein(OMgp). NgR plays an important role in cell adhesion and migration ,apoptosis ,differentiation of neural stem cells,angiogenesis and vascular remodeling. NgR may be a key molecule of the molecular target therapy for glioma.