中文摘要：

自分泌运动因子（autocrine motility factor,AMF）能刺激细胞的迁移和运动,与肿瘤发生、转移、血管生成密切相关。近年来人们发现有3种AMF：ATX-t、ATX-m和PD-Ialpha,其中PD-Ialpha在脑中特异表达,在神经发育、生长和神经分化、神经外伤修复与神经性疼痛以及神经退行性疾病中具有重要的作用,提示AMF及其受体与神经系统的病理生理过程密切相关。该文就AMF及其受体在神经系统中的作用和作用机制作一综述,为相关的研究提供参考。

英文摘要：

Autocrine motility factor （AMF） plays an important role in the stimulation of the migration and motility of cells,especially the generation,migration and angiogenesis of tumor.Recently,it has been found that AMF has three isoforms,ATX-t,ATX-m and PD-I alpha.The PD-I alpha isoform is specifically expressed in the brain,which plays extensive functions in nervous system,such as regulating neural development and differentiation,promoting neurotrauma repair,inducing neuropathic pain,even contributing neurodegeneration under some circumstances.This indicates the close relationship of AMF/AMFR and the pathophysiology of the nervous system.This paper mainly reviews the function of AMF and AMFR and its possible mechanism in the nervous system.