中文摘要：

采用硅胶、聚酰胺层析方法从构棘果中分离得到了4个苯并吡喃异黄酮alpinumisoflavone（1）、4＇-O-methylalpinmumisoflavone （2）、4＇-O-methylderrone （3）、isoderrone （4）和2个三萜化合物（13α,14β,17 α,20R）-lanosta-7,24-diene-3β-ol（5）、（13α,14β,17α,20R）-lanosta-7,24-diene-3β-O-actate （6）.以异黄酮isoderrone为原料进行了结构修饰得到5个新异黄酮衍生物.所有异黄酮均采用噻唑蓝蛋白染色（MTT）法对胃癌细胞SGC-7901的毒性进行了活性筛选,其中化合物4和10对人胃癌SGC-7901肿瘤细胞有中等程度的抑制作用.

英文摘要：

Four benzopyranylisoflavones including alpinumisoflavone （ 1 ）, 4 ＇ -O-methylalpinmumisoflavone （2）, 4＇ -O-methylderrone （3）, and isoderrone （4） along with two triterpenoid compounds （ 13α, 14β, 17α,20R） - lanosta-7,24-diene-3/3-ol （5） and （ 13α, 14β,17α,20R） -lanosta-7,24-diene-3/3-O-actate （6） were isolated from the fruits of Cudrania cochinchinensis. In addition, five new isoflavone derivatives （7 - 11） were also obtained by the methods of selective methylation, ethylation and O-prenylation using natural isoderrone 4 as a starting material. All isoflavones were tested for the cytotoxicity against SGC-7901 cell lines by MTT method. The result showed that compounds 4 and 10 have moderate cytotoxicity against SGC-7901 cell lines.