中文摘要：

从丰富易得的柚皮苷（Naringin）1出发,通过酸水解得到了柚皮素2.以柚皮素为先导化合物,通过4位羰基与水合肼作用合成了中间体柚皮素腙3,进而与各种不同类型的醛缩合,合成了14个新型N苯亚甲基柚皮素腙及类似物（4a～4n）.MTT蛋白染色法体外抑制肿瘤增值活性测试显示化合物4c、4d、4h、4j、4n对胃癌细胞SGC 7901有一定的抑制作用.

英文摘要：

Intermediate naringenin hydrazone （3） were genera dition and then reacted with hydrazine hydrate using natural N-benzylidene naringenin hydrazones （4a-4n） were synthesi hydes respectively. And the cytotoxity against human cane pounds were also evaluated by MTT. The results showed 4c toxity against SGC-7901.