中文摘要：

紫外线抵抗相关基因（UVRAG）最初是在着色性干皮病紫外线照射敏感性基因筛查中发现的,哺乳动物中的UVRAG与酵母菌Vps38具有同源性。作为肿瘤抑制基因,UVRAG频繁参与人类各种恶性肿瘤的发生发展,同时,UVRAG在细胞的自噬、凋亡和膜运输中发挥着关键性的作用。新的研究发现UVRAG在哺乳动物胚胎发育过程中器官反转阶段也起着非常重要的作用。本文主要对UVRAG的结构和功能的研究进展进行综述。

英文摘要：

UV radiation resistance-associated gene（UVRAG）was originally discovered in the gene screening of the ultraviolet radiation sensitivity of xeroderma pigmentosum disease and the UVRAG of the mammals was identical with the Vps38 of the yeast.As a tumor suppressor gene,UVRAG was frequently involved in the development of a variety of human malignancies.Simultaneously,UVRAG played a critical role in cell autophagy,apoptosis and membrane transport.New study found that UVRAG playsed a very important role in organ reversed phase in mammalian embryonic development process.This paper will summarize the updated structure and function of UVRAG.