原发性胃癌是世界范围发病率最高的恶性肿瘤之一,男性发病率是女性的2倍左右。男性和女性胃癌发病率的比例在不同地区和种族间没有差异,60岁以前随年龄的增长而上升。经典流行病学和分子流行病学研究证实,胃癌发病的性别差异是由慢性感染、饮食习惯、基因变异、遗传易感性、雌激素作用和生活方式行为差异等多种因素协同作用的结果。对于上述危险因素的研究,不仅有助于阐明胃癌的发生机制,更有助于完善胃癌的防控策略,进一步降低胃癌发生率。
Primary gastric cancer (GC) is one of the most frequently diagnosed cancers worldwide. The incidence of GC in male is approximately twice age, the male-female ratio of GC incidence has no the incidence thereof in female. Before 60 years of geographi increase of age. Studies of classic and molecular epidemiology c and ethic differences, and rises with the have proved that the sexual dimorphism in GC is due to synergetic effects of various factors including chronic infection, dietary habit, gene mutation, genetic Susceptibility, estrogenic effects and differences in lifestyle behaviors, etc. Studies on the above- mentioned factors can not only help clarify the carcinogenesis of GC, but also help improve the strategies of GC control and prevention, and reducing GC incidence subsequently.