中文摘要：

目的 探讨维生素D缺乏及不足的老年原发性高血压病患者补充维生素D后对其收缩压（SBP）、舒张压（DBP）及空腹血糖（FPG）的影响.方法 于2012年9月整群抽取乌鲁木齐市六道湾社区老年人199例,检测血清维生素D、血钙、FPG,测量身高、体质量、血压.根据是否患高血压分为高血压组98例和血压正常组101例.同时根据血清维生素D水平随机选取维生素D缺乏及不足的原发性高血压病患者60例,采用自身对照方法,在常规降压治疗的基础上加服罗盖全（骨化三醇胶囊）,连续服用3个月后比较服药前后以上指标的差别.结果 高血压组FPG、体质指数（BMI）均高于血压正常组[FPG：（6.1±0.5） mmol/L比（5.8±0.5） mmol/L; BMI：（25.7±4.1）kg/m2比（23.6±3.1） kg/m2],维生素D、血钙低于血压正常组[维生素D：（14±8） μg/L比（18±10） μg/L;血钙（2.26±0.10） mmol/L比（2.29±0.13） mmol/L],差异均有统计学意义（P＜0.05）.与维生素D不足组及充足组相比,维生素D缺乏组FPG高、血钙低[FPG：（6.1 ±0.5） mmol/L比（5.8±0.6） mmol/L比（5.7±0.5）mmol/L;血钙：（2.26±0.11） mmol/L比（2.32±0.09） mmol/L比（2.31 ±0.12） mmol/L],差异有统计学意义（P＜0.05）.Pearson相关性分析提示血清维生素D水平与FPG呈负相关（r=-0.192,P＜0.01）,与血钙呈正相关（r=0.247,P＜0.01）.补充维生素D后SBP、DBP、FPG均低于原水平[SBP：（131±13） mm Hg比（141±13） mm Hg;DBP：（83±10） mmHg比（89±11）mm Hg;FPG：（5.9 ±0.5）mmol/L比（6.1±0.6）mmol/L],维生素D、血钙均高于原水平[维生素D：（16±5）μg/L比（14±5） μg/L;血钙：（2.34 ±0.14） mmol/L比（2.28 ±0.14） mmol/L],差异均有统计学意义（P＜0.05）.结论 老年原发性高血压病患者较血压正常者血糖高,更易发生维生素D缺乏.补充维生素D能够降低老年原发性高血压病患者的血压及血糖水平.

英文摘要：

Objective To investigate the effect of vitamin D supplementation to elderly hypertensive patients suffering from vitamin D deficiency on the systolic blood pressure （SBP）,diastolic blood pressure （DBP） and fasting blood glucose （FPG）.Methods A random sample of 199 elderly residents at Six Bay community in Urumqi city in Sept,2012,were examined the serum levels of vitamin D,calcium and fasting plasma glucose,the height,the weight and the blood pressure.According to whether the risk of high blood pressure was divided into 98 cases of hypertension group and 101 cases of normal group.According to the levels of serum vitamin D lack and deficiency,60 patients with essential hypertension randomly selected were asked to continuously take Luogaiquan （Calcitriol capsule） besides conventional therapy for three months and afterwards compare the above indexes of pre-treatment and post-treatment respectively.Self-control designed was adopted in the experiment.Results The data suggested that body mass index （BMI）,blood pressure and fasting plasma glucose in abnormal blood pressure group were higher than normal blood pressure group [FPG：（6.1 ±0.5） vs.（5.8 ±0.5） mmol/L; BMI：（25.7 ±4.1） vs.（23.6 ± 3.1） kg/m2],while vitamin D level and blood calcium were lower than those in the normal blood pressure group [vitamin D：（14 ± 8） vs.（18 ± 10） μg/L; blood calcium （2.26 ± 0.10） vs.（2.29 ± 0.13） mmoL/L] and the differences were all significant （P ＜ 0.05）.Compared with the relative deficiency group and adequate group,in the vitamin D deficiency group FPG was higher,serum calcium was lower [FPG：（6.1±0.5） vs.（5.8±0.6） vs.（5.7±0.5） mmol/L,blood calcium：（2.26 ±0.11） vs.（2.32 ±0.09） vs.（2.31 ±0.12） mmol/L; all P ＜0.05].Pearson correlation analysis showed that serum vitamin D level was negatively correlated with FPG level （r =-0.192,P ＜0.01） and positively with serum calcium （r =0.247,P ＜ 0.01）.After supplying Vitamin D,systoli