中文摘要：

利用所构建的BALB/c小鼠子宫内膜异位症（EMs）模型,通过对正常和EMs小鼠在位子宫内膜样品双向电泳图谱的比较,找到61个差异较明显的蛋白质斑点,结合质谱分析技术和数据库信息检索最终鉴定出23个蛋白,包括11个调控蛋白、4个信号转导相关蛋白、1个代谢相关蛋白、5个膜联蛋白、1个细胞骨架蛋白和1个RNA解旋酶.将蛋白质组学技术应用于EMs的研究,可以从分子水平探索EMs的发病机理,对EMs的诊断及治疗具有重要意义.本研究结果为进一步探索EMs发病机理提供实验基础,同时也为寻找该病早期诊断的标志物和治疗的靶点提供理论依据.

英文摘要：

Based on the established endometriosis BALB/c mice model,the differential expression of eutopic endomereium proteins from the normal and endometriosis mice were compared by two-dimensional electrophoresis.There are 61 spots of significant differential proteins to be found.Among them,23 protein-spots were identified by mass spectrometry.They were 11 kinds of regulation-related proteins,4 kinds of signal transduction-related proteins,1 kind of metabolism-related proteins,5 kinds of membrane associated proteins,1 kinds of cyskeletal proteins and 1 kinds of RNA helicase enzymes,respectively.The application of proteomics in EMs research would be important for the study of the mechanism and should be significant in the diagnosis and treatment of the disease.The results would provide a theory foundation for studying the pathogenesis of endometriosis and some academic thereunder for searching early diagnosis marker and therapeutic target.