中文摘要：

随着对口服抗糖尿病药物研究的不断深入,目前已证实格列苯脲能够安全有效地治疗妊娠期糖尿病。格列苯脲具有较低的胎盘透过率,对其进行的相关胎盘转运机制研究发现,格列苯脲几乎不透过胎盘可能与多种转运蛋白有关,包括ATP结合盒式蛋白及有机阴离子转运肽。

英文摘要：

With the in - depth study of oral hypoglycemic drugs, the safe- ty and effectiveness of glyburide in the treatment of gestational diabetes has been confirmed. Related studies showed that glyburide had a lower placental transmission. And the studies about placental transport mecha- nisms showed that it might be associated with a variety of transport pro- teins, including ATP （ adenosine 5＇ - triphosphate ） - binding cassette （ABC） transporters and organic anion transporting polypeptides （OATPs）