中文摘要：

在动物开发期间指定并且维持细菌房间的特征的机制糟糕被理解。在这研究，我们证明锌手指基因 lsy-2 的功能的损失导致采用细菌房间特征的各种各样的体的房间，包括 germline 特定的 P 小粒，提高的 RNAi 活动和 transgene silencing 的表示。到在 lsy-2 异种的细菌转变的身体要求改变建筑群的多重染色质的活动，包括 MES-4 建筑群和 ISW-1 建筑群。在体的房间和基因表示侧面的不同 germline 特定的特征显示 LSY-2 在这个过程在 Mec 建筑群行动。我们的学习证明 lsy-2 在身体细菌区别的维护工作。

英文摘要：

The mechanisms that specify and maintain the charac- teristics of germ cells during animal development are poorly understood. In this study, we demonstrated that loss of function of the zinc-finger gene Isy-2 results in various somatic cells adopting germ cells characteris- tics, including expression of germline-specific P gran- ules, enhanced RNAi activity and transgene silencing. The soma to germ transformation in Isy-2 mutants requires the activities of multiple chromatin remodeling complexes, including the MES-4 complex and the ISW-1 complex. The distinct germline-specific features in somatic cells and the gene expression profile indicate that LSY-2 acts in the Mec complex in this process. Our study demonstrated that Isy-2 functions in the mainte- nance of the soma-germ distinction.