中文摘要：

目的：考察参麦注射液（SMI）对心衰（HF）犬内源性洋地黄样物质（EDLS）的影响。方法：将造模成功4周后的心衰犬20只随机分为对照组和SMI低、中、高剂量组,每组5只。对照组予生理盐水20mL,低、中、高剂量组分别予SMI0.517、1.034、1.551mL/kg（用生理盐水稀释至20mL）静脉推注qd×7。分别于第1d给药后即刻、0.5、2、4、8、12h时点,第7d给药后即刻、0.5、2、4、8、12h时点取静脉血2mL,用RIA法测定血清EDLS浓度。结果：SMI可提高心衰犬血清EDLS浓度,且随给药剂量和次数的增加呈现出一定的量效关系和累积效应。结论：SMI对心衰犬血EDLS具有动态调控作用。

英文摘要：

Objective：To investigate the effect of Shenmai Injection（SMI） on endogenous digitalis-like substance（EDLS） in the model dogs with heart failure（HF）.Methods：Twenty model dogs with HF were randomly divided into 4 groups：the control one（0.9% NaCl injection 20 mL iv qd ×7,n=5） and the low,middle and high dose ones of SMI（administrated by 0.517,1.034 and 1.551mL/kg,diluted to 20 mL with 0.9% NaCl injection,iv qd ×7,n=5）.On the 1st and the 7th day separately,blood samples（2mL） were collected before and after administration at 0h and 0.5h,2h,4h,8h and 12h.The EDLS concentration in serum was determined by radio-immunity assay（RIA）.Results：SMI could elevate the blood concentration of EDLS and showed accumulating effect with its administration dose and times increasing.Conclusion：SMI had the dynamic regulation effect on EDLS in model dog with HF.