中文摘要：

象 ubiquitin 一样修饰词 bISG15 是在胎儿的牛的肺(FBL ) 发现房间的抗病毒的蛋白质。牛的 Herpesvirus 1 (BHV-1 ) 是牛的病毒的病原体，能感染 FBL 房间并且导致 cytopathic 效果。实时 PCR 试金证明 BHV-1s 感染能镇压在 FBL 房间的 bISG15 的基础或可诱导的抄写。它证明这压抑效果取决于 BHV-1 病毒的感染和新蛋白质合成。我们的以前的工作证明 bIRF-3 是在在 FBL 房间的 bISG15 的刺激的关键因素，因此激活 bISG15 的倡导者的 bIRF-3 上的 BHV-1 病毒的蛋白质的效果被证实。酶试金证明 BHV-1 病毒的蛋白质 bICP0 禁止了 bIRF-3 刺激的 bISG15 倡导者的激活。一起拿，我们的工作建议 BHV-1 有某分子的机制抵抗细胞的 bISG15s 抗病毒的功能。

英文摘要：

The ubiquitin-like modifier bISG15 is an antiviral protein found in fetal bovine lung （FBL） cells. Bovine Herpesvirus 1（BHV-1）, which is a viral pathogen of cattle, can infect FBL cells and induce cytopathic effects. Real-time PCR assays showed that BHV-l＇s infection could repress the basal or inducible transcription of bISG15 in FBL cells. It demonstrates that this repression effect depends on BHV-1 viral infection and new protein synthesis. Our previous work showed that bIRF-3 was the key factor in the stimulation ofbISG15 in FBL cells, so the effect of BHV-1 viral protein on bIRF-3 activating the promoter of bISG15 was confirmed. The luciferase assay showed the BHV-1 viral protein bICP0 inhibited the activation of bISG15 promoter stimulated by bIRF-3. Taken together, our work suggested that BHV-1 had some molecular mechanism to resist the cellular bISG15＇s antiviral functions.