中文摘要：

乳腺癌是最常见的女性癌症,其发生是遗传因素和环境因素相互作用的结果。因此,我们就CYP1A1MspⅠ（m1多态）、CYP1B1 Leu432Val、NET T-182C、DAT1-VNTR等基因多态性对新疆汉族人群乳腺癌易感性的研究进行探讨。在以144例乳腺癌患者和120例正常对照组为研究对象的病例-对照研究中,发现CYP1A1MspⅠ位点CC基因型、C等位基因（OR=3.32,95%CI：1.24-8.86;OR=1.58,95%CI：1.09-2.31）和高风险联合基因型CYP1A1 MspⅠ与CYP1B1 Leu432Val,CYP1A1 MspⅠ与DAT1-VNTR,CYP1B1 Leu432Val与DAT1-VNTR（OR=2.43,95%CI：1.23-4.78;OR=4.53,95%CI：1.26-16.27;OR=2.98,95%CI：1.10-8.06）与乳腺癌风险增加有关。CYP1B1、NET和DAT1基因多态性与乳腺癌易感性无关。这些研究结果表明,CYP1A1 MspⅠ多态性和CYP1A1、CYP1B1、DAT1高风险联合基因型能增加新疆汉族人群患乳腺癌的风险。

英文摘要：

Breast cancer is a very common cancer in women and caused by a complex combination of genetic and environmental factors. Here we investigated the effect of CYP1A 1 Msp I （ml polymorphism）, CYP1B1 Leu432Val, NET T-182C and DA T1-VNTR polymorphisms on the susceptibility of breast cancer in the Han population in Xinjiang, China. In case-control study of 144 breast cancer patients and 120 agematched healthy controls, we found that C/C genotype and C allele of CYP1A 1 Msp I （OR=3.32, 95% CI： 1.24-8.86; OR=1.58, 95% CI： 1.09-2.31, respectively） and the high-risk combination genotypes of CYP1A 1 Msp I with CYP1B1 Leu432Val, CYP1A 1 Msp I with DAT1-VNTR and CYP1B1 Leu432Val with DA T1-VNTR （0R=2.43, 95% CI： 1.23-4.78; OR=4.53, 95% CI： 1.26-16.27; OR=2.98, 95% CI： 1.10-8.06, respectively） were associated with the increased risk of breast cancer. The polymorphisms of CYP1B1, NET and DA T1 exhibited no significant association with breast cancer. These results suggest that the CYP1A 1 Msp I polymorphism and the specific high-risk combination genotypes of CYP1A 1, CYP1B1 and DAT1 contribute to an increased risk of breast cancer among the Han population of Xinjiang, China.