中文摘要：

目的：探讨血管紧张素转换酶（ACE）基因16内含子插入/缺失（I/D）多态性与新疆维吾尔自治区汉族人群异常体液型2型糖尿病（type 2 diabetes mellitus,T2DM）的关系。方法：用维吾尔医学和分子生物学技术互相结合的方法,分析87例T2DM患者和157例正常人ACE基因16内含子I/D多态性。结果：（1）异常粘液质型T2DM组II基因型的频率较对照组显著增高（20.00%比4.43%,p=0.023〈0.05）。（2）在异常粘液质型T2DM组中携带ID、DD基因型的个体较携带II基因型的个体患T2DM的危险性增加（OR=5.618,95%CI为1.451-21.739;OR=4.386,95%CI为0.785-24.390）。结论：ACE基因16内含子插入/缺失（I/D）多态性与新疆汉族人异常粘液质型T2DM的危险性相关,与新疆汉族人异常胆液质型、异常黑胆质型和异常血液质型T2DM的危险性无关。

英文摘要：

Objective： To study the I / D polymorphism of ACE gene and it＇s susceptibility to type 2 diabetes（ T2DM） in chinese Han population of Xinjiang. Method： Using the combined methods of Uighur medicine theory and molecular biology techniques to detect the I / D polymorphism at the intron 16 of the ACE gene in 87 T2 DM patients and 157 controls. Result：（ 1） The frequency of the Ⅱ genotype for patients with abnormal Balgham Hilit was significantly higher than these for controls（ 20. 00% vs 4. 43%,p = 0. 023 0. 05）.（ 2） Compared with II genotype,the susceptibility to T2 DM with the ID,DD genotypes were increased by 5. 618（ OR = 5. 618,95% CI 为 1. 451-21. 739） and 4. 386（ OR = 4. 386,95% CI 为 0. 785- 24. 390） in T2 DM patients with abnormal Balgham Hilit. Conclusion： These data suggest that the polymorphism of I / D of ACE gene have a susceptibility to T2 DM risk in patients of chinese Han population which carried with abnormal Balgham Hilit,and it is not associated with T2 DM risk in patients with uighur medicine abnormal Savda Hilit,uighur medicine abnormal Sapra Hilit and uighur medicine abnormal Qan Hilit.