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中文摘要：
用聚乙二醇PEG1000和4600引发乙交酯（GA）和L-丙交酯（L-LA）开环共聚合得到一系列数均分子量为3000—7000的PLGA—PEG-PLGA水凝胶材料．综合应用动态粘弹谱仪和相图，系统报道了该凝胶力学性质和溶胶-凝胶转变的关系，凝胶区间的模量在10^2～10^4Pa之间．用荧光光谱证明了该三嵌段聚合物形成胶束的性质并测定了临界胶束浓度，验证了凝胶由胶束形成的机理．凝胶中的头孢他定释放呈现一定程度的缓释作用．
英文摘要：
A series of PLGA-PEG-PLGAs with Mn = 3 000-7 000 were synthesized by ROP of L-lactide and glycolide with PEG（M, = 1 000 and 4 600） as the initiators. The dynamic viscoanalyser and phase diagram were utilized to investigate the mechanical properties with sol-gel transition of the hydrogel system, and the G＇ and G＂ were between 10^2 and 10^4 Pa. Also, the fluorescence spectroscopy of PLGA-PEG-PLGA micelle solution was investigated to reveal the gelation mechanism of hydrogel. Finally, the controlled release of ceftazidime from the hydrogel was observed.
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