中文摘要：

目的探讨贵州省部分地区神经系统疾病中博尔纳病病毒（Borna disease virus,BDV）感染情况以及病毒性脑炎阳性患者的临床特征。方法采用酶联免疫吸附试验（ELISA）检测84例神经系统疾病患者[包括病毒性脑炎（VE）患者69例,吉兰-巴雷综合征（GBS）患者9例,多发性硬化（MS）患者6例,以及45例对照组（非炎症性神经系统疾病患者）]脑脊液（CSF）中BDV循环免疫复合物（CIC）及抗体,对13例脑脊液BDV CIC阳性患者同期行血液BDV CIC检测。结果 84例神经系统疾病患者CSF中BDV CIC总阳性率为15.4%（13/84）,其中VE阳性率14.4%（10/69）,GBS阳性率11.1%（1/9）,MS阳性率33.3%（2/6）,对照组阳性率2.22%（1/45）,实验组总体阳性率明显高于对照组（P〈0.05）,两组比较具有统计学意义。CSF抗体阳性率1.2%（1/84）,对照组抗体阳性率为0。两组比较无统计学意义（P〉0.05）。血液BDV CIC阳性标本10例。7例BDV CIC阳性病毒性脑炎患者主要以精神行为异常为特征,患者有密切动物接触史。结论贵州省部分地区等地神经系统疾病中存在BDV感染,7例VE患者主要以精神行为异常为临床特征。

英文摘要：

To study the infectious situation of Borna disease virus （BDV） in patients with neurological disorders and clinical features of viral encephalitis-positive patients in some areas of Guizhou province, enzyme-linked immunosorbent assay was employed to detect BDV circulating immune complex （CIC） and antibody in cerebrospinal fluid （CSF） of 84 patients with neurological diseases, including 69 cases of viral encephalitis, 9 cases of Guillain-Barre syndrome, and 6 cases of multiple sclerosis, with 45 cases of control group （non-inflammatory of neurological disorders）. In addition blood BDV CIC was detected in 13 cases of patients with positive CSF BDV CIC. Then experimental data was analyzed by statistical method. In CSF of 84 cases with neurological disorders, total BDV CIC positive rate was 15.4% 03/84）, in which VE patient was 14.4% （10/69）, GBS patient was 11.1% （1/9）, MS patient was 33.3% （2/6）. While BDV CIC positive rate was 2.22% （1/45） in control group, which was significantly lower than that of neurological disorders patients （P〈0.05）; CSF antibody positive rate was 1.2% （1/84） in experimental group, while that in control group was 0 （P〉0.05）. There were 10 cases of blood BDV CIC-positive. Seven cases of BDV CIC-positive patients with viral encephalitis had contacted animal closely, and demonstrated a feature of mainly mental and behavior disorders. All the result indicated that BDV infection possibly exists in neurological disorders in some areas of Guizhou province. And 7 VE patients mainly have the clinical features of mental and behavior disorders.