中文摘要：

设计合成了一系列2-甲基-6-硝基苯磺酰脲衍生物（4a~4p）,通过核磁共振氢谱（1H NMR）和高分辨质谱（HRMS）对其结构进行了确认.盆栽法除草测试结果表明,在300 g/ha剂量下,目标化合物具有优异的芽前或芽后除草活性.进一步筛选发现,在75 g/ha剂量下,化合物4b,4g,4h,4l和4p对油菜、反枝苋和稗草具有98%以上的除草活性,与对照药单嘧磺隆（100%）和氯磺隆（≥96.3%）相当.另外,部分化合物对真菌也表现出一定的抑制效果,其中化合物4l对油菜菌核病菌的半最大效应浓度EC50=9.20 mg/L（对照药多菌灵的EC50=5.79 mg/L）.

英文摘要：

In order to search for new compounds with high efficacy herbicidal activity,a series of novel sulfonylurea derivatives was designed and synthesized referring to the commercialization sulfonylurea skeletons：Monosulfuron and Triflulsulfuron-methyl.The title compounds were prepared by multistep synthetic procedures starting from 2-methyl-6-nitroaniline,and their chemical structures were characterized by1 H NMR and HRMS.The bioassay results indicate that some of the title compounds show excellent herbicidal activities at the dosage of 300 g / ha.Further study found that compounds 4b,4g,4h,4l and 4p are as effective as Monosulfuron（100%） and Chlorsulfuron（≥96.3%） against Brassica napus,Amaranthus retroflexus L.and Echinochloa Crusgalli at the dosage of 75 g / ha.Preliminary fungicidal test showed some target compounds also hold good antifungal activity in vitro.Particularly,the EC50 of compound 4l against Sclerotinia sclerotiorum was 9.20 mg/L（Carbendazim,EC50= 5.79mg/L）.