中文摘要：

osthole 的结构被修改了对蚊子改进它的 larvicidal 活动。有 Grignard 试剂的 osthole 衍生物的新有效合成被开发了，它作为倡导者采用 CuI 和 LiCl 并且盖住大量底层负担得起相应产品在对好收益(多达 83%) 温和。简历活动评估证明几个产品比 osthole 展出了更好的活动。

英文摘要：

The structure of osthole has been modified to improve its larvicidal activity against mosquitoes. A new efficient synthesis of osthole derivatives with Grignard reagents has been developed, which employs CuI and LiCI as pro- moters and covers a broad range of substrates to afford the corresponding products in mild to good yields （up to 83%）. Bio-activity evaluation showed that several products exhibited better activities than osthole.