中文摘要：

目的：论述以血管内皮生成因子（VEGF）及其受体VEGFR为靶点的肺癌的研究现状,探讨VEGF及VEGFR与肺癌发生及发展的关系,为肺癌抗血管生成的治疗提供新的药物作用途径。方法：依据近年国内外的相关文献,进行归纳和分析,对VEGF及肺癌发生相关系统进行研究,并在此基础上,提出肺癌抗血管治疗的新思路。结果：研究发现,在肺癌的发生及发展过程中,VEGF出现过量表达。为达到抑制其促血管生成的作用,以VEGF/VEGFR为靶点,研制抑制VEGF活性的药物或干扰VEGFR的药物,可在一定程度上实现通过抑制相关抗血管生成治疗肺癌的目的。结论：利用新的抗血管途径有望在肺癌治疗中研发出新药,提高肺癌治疗效果。

英文摘要：

Objective： To provide a new way of anti-angiogenic drug treatment for lung cancer by studying the research status of lung cancer targeting vascular endothelial growth factor（VEGF） and its receptor VEGFR,and discussing the relationship between VEGF/ VEGFR and the occurrence and development of lung cancer.Methods： Summarizing and analyzing the relationship between VEGF and related systems in lung cancer based on the literatures both at home and abroad in recent years.Results： VEGF is overexpressed in the development process of lung cancer.To inhibit angiogenesis effect of VEGF/VEGFR,to some extent,some new drugs could be found to treat the lung cancer.Conclusion： When the new drugs are developed in the new anti-angiogenic pathway,the treatment of lung cancer will be improved.