中文摘要：

目的：建立适用于组织工程骨需求的支架材料CAD空间构型，支架结构实体微观模型及生物可降解组织工程骨支架。方法：将螺旋CT获得的DICOM格式文件输入MIMICS软件，将其生成的三维模型导人GEOMAG-Ic软件，提取外层轮廓，利用偏移功能模拟得到外层皮质骨。利用CATIAV5R17软件构建支架材料空间内部多孑L微观模型单体，在空间合适坐标上阵列得到组织工程骨内部支架整体模型，通过变更单体构型快速建立多种整体支架构型。装配皮质骨与内部空间支架得到STL文件。采用PROJETTM3500三维打印机成型材料为光固化丙烯酸树脂，支撑材料为无毒可分解石蜡打印该模型，得到组织工程骨实体模型。后期利用生物可降解材料结合固高GXYZ303010-XYLE三维打印系统打印得到可降解组织工程骨支架。结果：成功的建立了骨组织支架微观结构CAD模型，并成功构建出该模型实体及生物可降解组织工程骨支架。结论：基于结合计算机逆向与正向工程建模技术，可快速建立多种符合组织工程骨要求的支架材料空间构型。其仿生三维微观模型对三维打印组织工程骨有着积极意义，结合三维打印机及适合的生物可降解材料便可快速成型出植入所需的组织工程骨生物支架。

英文摘要：

Objective： To find a way to establish a series of three dimensional digital mode for tissue engineering bone 3D-printing,finally forming a series of light curing acrylic resin solid models and biodegradable tissue engi- neering bone scaffolds. Methods： In order to get 3D-printing format of STL （Standard Template Library） files, we input CT data of DICOM format to MIMICS and GEOMAGIC software, and create cortical bone STL files. We use CATIA software to cerate scaffold three dimensional digital mode of tissue engineering bone. The cortical bone and the scaffold were assemblied. We input the mode to PROJET TM 3500 3D-printing machine to cerate the target artificial bone, the forming material and the gUpp0rt material is light curing acrylic resin and non-toxic paraffin. U sing synthetic biodegradable materials we can get biodegradable tissue engineering bone scaffold by 3D printing. Re suits： We got this CAD model and biodegradable tissue engineering bone scaffold. Conclusion： 3D digital mode based on reverse engineering and positive engineering is established. This technique has far-reaching significance in the application of 3D printing tissue engineering bone scaffold . The digital mode can be direct application by 3D printing technique, use the right biodegradable tissue we will get the target biodegradable tissue engineering bone scaffold.