中文摘要：

目的研究细圆藤[Pericampylus glaucus（Lam.）Merr.]的三萜类化学成分及其抗肿瘤活性。方法采用各种色谱技术分离纯化三萜类化合物,根据理化性质及波谱数据鉴定结构。采用MTT法测试三萜化合物的抗肿瘤活性。结果从细圆藤枝叶中分离鉴定了5个五环三萜类化合物,分别是hopenone-B（1）、hopenol-B（2）、22-hydroxyhopan-3-one（3）、erythrodiol3-palmitate（4）、5β,24-cyclofriedelan-3-one（5）。化合物4对K562细胞增殖有抑制作用,在100μg·mL^-1质量浓度下抑制率为47%,其余化合物无明显抑制作用。结论化合物1-5为首次从细圆藤属植物中分离得到,其中4为细圆藤抗肿瘤活性成分的首例报道,其抗肿瘤活性也是首次报道。首次报道化合物2的^13C-NMR谱数据以及化合物1和5的^1H-NMR、^13C-NMR谱数据。

英文摘要：

Aim To investigate triterpenoidal constituents of Pericampylus glaucus（ Lam. ） Merr. and to evaluate their antitumor activities. Methods Various chromatographic means were used for the isolation of triterpenes and the compounds obtained were identified by the spectroscopic method. Antitumor activities were also assayed by MTT method. Results Five triterpenes were isolated from Pericampylus glaucus and identified as hopenone-B （ 1 ）, hopenol-B （ 2 ）, 22-hydroxyhopan-3-one （ 3 ）, erythrodiol 3-palmitate （ 4 ）, and 5β,24-cyclofriedelan-3-one（ 5 ）, respectively. Among them ,compound 4 inhibited the proliferation of K562 cells with the inhibition rate of 47% at 100 μg ·mL ^-1 ,while others did not show inhibitory effect at the concentration tested. Conclusion Compounds 1 -5 were isolated from the genus Pericampylus for the first time. Compound 4 is the first reported antitumor constituent of Pericampylus glaucus and its antitumor activity was also assayed for the first time. The ^13C-NMR data for 2 and the ^1H-NMR and ^13C-NMR data for 1 and 5 were reported for the first time.