目的:调查中国大陆帕金森病(Parkinson’s disease,PD)患者microRNA-7基因的变异。方法:对225例汉族PD患者应用DNA测序技术进行microRNA-7基因突变分析。结果:在本组PD患者中未发现microRNA-7变异。结论:MicroRNA-7基因突变不是导致中国人群罹患PD的主要因素。
Objective:To investigate the mutation of small sequence changes in microRNA-7 gene in Chinese patients with Parkinson’s disease(PD).Methods: We analyzed miR-7 variants in 225 PD patients from Chinese Han group by DNA sequence.Results: None of the patients had miR-7 variants.Conclusion: MiR-7 variation is not associated with PD in Chinese patients.