中文摘要：

背景尿酸( UA )被怀疑在 Parkinson .This 学习试图评估浆液 UA 水平是否在中国 patients.Methods 浆液 UA 层次的一张相对大的人口与 PD 的疾病前进被联系的疾病( PD )起一个neuro保护的作用从 411 个中国 PD 病人被测量并且 396 匹配年龄的控制；跟随尿酸比色的方法，浆液 creatinine (Scr ) 层次也被测量减少可能的差别在肾的排泄 function.The 引起的偏爱疾病前进被 Hoehn 和 Yahr (H&Y ) 规模和疾病持续时间获得； PD 组根据 H&Y scales.Independent样品 ttest 被划分成 3 亚群被执行分析 PD 组之间的差别，协变性的控制 group.Multiple 分析被执行分析 PD subgroups.Spearman 等级关联之间的差别被执行评估在水平和疾病 progression.Results PD 病人被发现的浆液 UA 或 Scr 之间的协会显著地比控制有浆液 UA 的底层(( 243.38

英文摘要：

Background Uric acid （UA） is suspected to play a neuro-protective role in Parkinson＇s disease （PD）.This study aimed to evaluate whether the serum UA level was associated with the disease progression of PD in a relatively large population of Chinese patients.Methods Serum UA levels were measured from 411 Chinese PD patients and 396 age-matched controls; following the uric acid colorimetric method,the serum creatinine （Scr） levels were also measured to reduce the bias caused by possible differences in renal excretion function.The disease progression was scored by Hoehn and Yahr （H＆Y） scales and disease durations; PD group was divided into 3 subgroups according to H＆Y scales.Independent-samples ttest was performed to analyze the differences between PD group and control group.Multiple analysis of covariance was performed to analyze the differences between PD subgroups.Spearman rank-correlation was performed to evaluate the associations between serum UA or Scr level and disease progression.Results PD patients were found to have significantly lower levels of serum UA than controls （（243.38±78.91） vs.（282.97±90.80） pmol/L,P〈0.01）.As the disease progression,the serum UA levels were gradually reduced.There was a significantly inverse correlation of UA levels with H＆Y scales （Rs=-0.429,P 〈0.01） and disease duration （Rs=-0.284,P 〈0.01） in PD patients of both females and males.No significant difference of the Scr level between PD patients and controls was found （（70.01±14.70） vs.（69.84±16.46） μmol/L）,and the Scr level was not involved in disease progression.Conclusion Lower serum UA levels may possess a higher risk of PD,which may be a potential useful biomarker to indicate the progression of PD.