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DNA损伤修复相关蛋白H2AX,ATM,CDKN1A,TP53辐射响应研究现状
  • ISSN号：1004-6356
  • 期刊名称：辐射防护通讯
  • 时间：2011
  • 页码：32-35
  • 分类：Q691[生物学—生物物理学]
  • 作者机构：[1]复旦大学放射医学研究所,上海200032
  • 相关基金：国家自然科学基金（30770644 31070758）
  • 相关项目：电离辐射与镉复合细胞效应及DNA甲基化在其中的作用
作者： 任瑞平|何明远|邵春林|
关键词： 生物学效应, 辐射损伤, 蛋白质, 生物剂量计, Biological effect Radiation damage Protein Biodosimetry
中文摘要：

人类受到照射后,至少有173种蛋白质表达水平增加和磷酸位点发生改变。本文介绍了DNA修复相关蛋白质H2AX、ATM、CDKN1A、TP53的生物学特性,以及不同品质和不同剂量射线诱发这些蛋白质响应研究现状。

英文摘要：

At least 173 proteins can be up-regulated or changed in their phosphorylation status in the human cells after irradiation.This article briefly introduced the characteristics of DNA repair-related proteins such as H2AX,ATM,CDKN1A,and TP53,and analyzed their responses to radiation of different quality and dose.

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电离辐射与镉复合细胞效应及DNA甲基化在其中的作用
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期刊信息
  • 《辐射防护通讯》
  • 主管单位:中国辐射防护研究院
  • 主办单位:中国辐射防护研究院
  • 主编：常学奇
  • 地址：太原市学府街102号
  • 邮编：030006
  • 邮箱：DEFE@chinajournal.net.cn
  • 电话：0351-2203447 2203457
  • 国际标准刊号：ISSN：1004-6356
  • 国内统一刊号：ISSN：14-1114/TL
  • 邮发代号:
  • 获奖情况:
  • 国内外数据库收录:
  • 被引量:1956