以苯并咪唑为原料,经硝化、二茂铁磺酰化等步骤,合成了8种未见文献报道的硝基苯并咪唑衍生物,其结构经MS,^1H NMR和元素分析确证.由于硝基苯并咪唑的互变异构,二茂铁磺酰化后,产生两个异构体,用X射线衍射仪测定了化合物2a的晶体结构.初步的抑菌实验结果表明,该系列化合物具有良好的抑菌作用,其抑菌活性均优于对照药剂50%多菌灵可湿性粉剂.
It was reported that benzoimidazole and ferrocene compounds maybe exhibit high pharmaceutical functions. Eight new nitrobenzoimidazole derivatives were prepared by the reaction of ferrocene sulfonylchloride with 5-nitrobenzoimidazole and characterized by means of elemental analysis, MS and ^1H NMR. The structure of the new compounds was further confirmed by X-ray crystallograghic analysis as exemplified by compounds 3b. The activities of compounds 3a-4d were evaluated against five fungicides. Compared with carbendazim(50% wet powder) , better inhibitory activities were observed for these synthesized compounds.