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中文摘要：
以2位环己基取代苯并咪唑盐作为甲酸氧化态的四氢叶酸辅酶模型，与亲核Grignard试剂作用，将甲酸氧化态的一碳单元转移给亲核试剂，成功地实现了6类具有潜在应用价值的环己基甲酮的绿色仿生合成，其结构用元素分析、^1HNMR、IR和MS等方法进行了表征，并对反应机理和反应条件进行了讨论．
英文摘要：
The tetrahydrofolate coenzyme is the methyl source of the methylation for many materials （including the DNA and RNA） in the living body to transfer one carbon unit for the biosynthesis and metabolism. On the basis of the one-carbon unit transfer reaction of tetrahydrofolate eoenzymes, six eyelohexyl ketone compounds were synthesized successfully with benzimidazolium salt as the tetrahydrofolate eoenzyme model at formic acid oxidation level and Grignard reagent as a nueleophile to which one carbon unit was transferred via addition-hydrolysis reaction. Their structures were characterized by elemental analysis, ^1H NMR, IR and MS spectra. A novel method for the convenient biomimetie synthesis of eyelohexyl ketone compounds was provided. The reaction mechanism and the effects of reaction conditions on the yield were investigated.
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同项目期刊论文
The Synthesis of dialdehyde from sodium hydrogen telluride with 1,1’, 3,3’-tetramethyl-2,2’-bisbenzi
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