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Non-coding Transcripts from Enhancers: New Insights into Enhancer Activity and Gene Expression Regulation
  • ISSN号:1672-0229
  • 期刊名称:《基因组蛋白质组与生物信息学报:英文版》
  • 分类:Q756[生物学—分子生物学] Q78[生物学—分子生物学]
  • 作者机构:[1]Center for Functional Genomics and Bioinformatics, Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, College of Life Science, Sichuan University, Chengdu 610064, China, [2]State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China
  • 相关基金:This work was supported by the National Key Research and Development Project (Grant No. 2017YFA0504300), the National Basic Research Program of China (973 Program; Grant No. 2011CB504203), the National Natural Science Foundation of China (Grant Nos. 81490752, 31671347, 31000579, 31371325, and 30971634), the Doctoral Programs Foundation of the Ministry of Education, China (Grant No. 20130181130010), and the Research Foundation of Sichuan University for Excellent Youth Scholars (Grant No. 2015SCU04A23).
中文摘要:

长非编码的 RNA (lncRNAs ) 由于他们的庞大的数量在过去的十年获得了普遍兴趣,令人吃惊的函数在许多生物进程含有。某 lncRNAs 作为 enhancers 施加功能,即,由用作 cis 规章的分子激活基因抄写。而且,最近的研究证明了许多 enhancer 元素能被抄录并且生产 RNA 分子,它作为 enhancer RNA (eRNAs ) 被称为。eRNAs 不仅仅是 enhancer 抄写的副产品。事实上,许多直接通过多样的机制在基因激活他们施加或调整 enhancer 活动。这里,我们在调整 enhancer 活动和基因表示提供 enhancer 活动, enhancer 本身的抄写, eRNAs 的特征,以及他们的角色的概述。

英文摘要:

Long non-coding RNAs (lncRNAs) have gained widespread interest in the past decade owing to their enormous amount and surprising functions implicated in a variety of biological pro- cesses. Some lncRNAs exert function as enhancers, i.e., activating gene transcription by serving as the cis-regulatory molecules. Furthermore, recent studies have demonstrated that many enhancer elements can be transcribed and produce RNA molecules, which are termed as enhancer RNAs (eRNAs). The eRNAs are not merely the by-product of the enhancer transcription. In fact, many of them directly exert or regulate enhancer activity in gene activation through diverse mechanisms. Here, we provide an overview of enhancer activity, transcription of enhancer itself, characteristics of eRNAs, as well as their roles in regulating enhancer activity and gene expression.

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期刊信息
  • 《基因组蛋白质组与生物信息学报:英文版》
  • 主管单位:中国科学院
  • 主办单位:中科院北京基因组研究所
  • 主编:
  • 地址:北京市朝阳区北土城西路7号中科院北京基因组研究所
  • 邮编:100029
  • 邮箱:editor@big.ac.cn
  • 电话:010-82995372
  • 国际标准刊号:ISSN:1672-0229
  • 国内统一刊号:ISSN:11-4926/Q
  • 邮发代号:82-557
  • 获奖情况:
  • 国内外数据库收录:
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  • 被引量:52