长非编码的 RNA (lncRNAs ) 由于他们的庞大的数量在过去的十年获得了普遍兴趣,令人吃惊的函数在许多生物进程含有。某 lncRNAs 作为 enhancers 施加功能,即,由用作 cis 规章的分子激活基因抄写。而且,最近的研究证明了许多 enhancer 元素能被抄录并且生产 RNA 分子,它作为 enhancer RNA (eRNAs ) 被称为。eRNAs 不仅仅是 enhancer 抄写的副产品。事实上,许多直接通过多样的机制在基因激活他们施加或调整 enhancer 活动。这里,我们在调整 enhancer 活动和基因表示提供 enhancer 活动, enhancer 本身的抄写, eRNAs 的特征,以及他们的角色的概述。
Long non-coding RNAs (lncRNAs) have gained widespread interest in the past decade owing to their enormous amount and surprising functions implicated in a variety of biological pro- cesses. Some lncRNAs exert function as enhancers, i.e., activating gene transcription by serving as the cis-regulatory molecules. Furthermore, recent studies have demonstrated that many enhancer elements can be transcribed and produce RNA molecules, which are termed as enhancer RNAs (eRNAs). The eRNAs are not merely the by-product of the enhancer transcription. In fact, many of them directly exert or regulate enhancer activity in gene activation through diverse mechanisms. Here, we provide an overview of enhancer activity, transcription of enhancer itself, characteristics of eRNAs, as well as their roles in regulating enhancer activity and gene expression.