中文摘要：

目的：观察参附注射液对心脏不同部位结扎大鼠的微循环状态的影响。方法：采用左冠状动脉前降支近心尖端、远心尖端结扎法造早、中期心源性休克大鼠模型,用Geneandi-M2型倒置微循环系统观察空白组、早、中期休克模型组,早、中期休克给药组大鼠各时段的红细胞流速、血管管径、白细胞黏附数及血管通透性。结果：参附注射液早期注射均使休克大鼠红细胞流速加快、血管管径变宽、白细胞黏附数减少、血管通透性降低,有效的改善休克大鼠微循环,其中10ml/kg早期给药组的微循环改善更为明显;中期给药组各时间点对休克大鼠红细胞流速、白细胞黏附数有较好的改善作用,但对血管通透性和血管管径未见明显改善。结论：早期给参附注射液治疗心源性休克的效应比中期给药的疗效更明显,这为心源性休克患者提早治疗提供理论依据。

英文摘要：

Objective： To observe the effect of Shenfu Injection（ SFI） on the microcirculatory disturbance in mesentery of rats with heart ligation in different sections.Methods： We ligated the end or root of left anterior descending coronary arteries（ LADCA） to mimic the early-and midstage of cardiogenic shock.The parameters in mesenteric microcirculation,such as velocity of RBCs in venules,diameters of venules,the count of leukocyte adhesion and vascular permeability which calculated by FITC-dextran leakage were observed through an Geneandi-M2 inverted intravital microscope and high-speed video camera system.Results： Ligating the LADCA of rats caused some syndromes in microcirculation,including a significant decrease of velocity of RBCs,narrowing of the vascular diameter,increase of counts of adhesive leukocytes and capillary permeability.The microcirculation parameters in rats with early-cardiogenic shock were improved by SFI,especially when the dosage was 10ml/kg.While there were no apparent-effect on the vascular diameter and permeability in mid-stage cardiogenic shock.Conclusion：The curative effect of early treatment with SFI was more apparent than that of the mid administration.