中文摘要：

针对复杂的大规模微流控芯片，提出了一种新的通用微流控系统行为模拟方法，计算芯片中由压力驱动的，线性和非线性的，静态和动态的溶液、溶质传输。对芯片中溶液/溶质传输的对流-扩散方程进行了分析，定义新的节点变量，抽象出系统集总模型，通过空间离散化处理，考虑了管壁柔性对模型参数的影响，建立毛细管传输的数值模型。新方法可以避免复杂解析解的求解，计算时间短。利用Verilog-AMS语言实现了模型建立和求解，开发了具体应用程序，对自制微流控开关梯度发生器及脉冲编码调制器进行模拟和分析，通过对比仿真和实验结果，验证了方法的有效性。

英文摘要：

A novel simulation method for obtaining approximate solution of linear and nonlinear, static and time-dependent solute and solvent transport in large chips was developed. The method was based on a one-dimensional space discretization of the convection-diffusion equation which tracks solvent and solute transport using four dual-branch nodal quantities. The lumped model was implemented in a hardware language such as Verilog-AMS and detailed codes were presented. Furthermore, comparison of the static and transient behavior of a microfluidic switching gradient generator and a PCM signal generator indicates that the experimental results are in good agreement with the model simulation.