中文摘要：

目的：通过实验观察大鼠心肌Cx43与心率增龄性改变，探究Cx43增龄性改变与心率之间的关系。方法：将30只大鼠按月龄分为3组，6月龄组、12月龄组和18月龄组大鼠各10只，通过免疫组化实验方法测定Cx43含量。并记录各组大鼠随年龄增长的心率，用SPSS19．0对实验数据进行统计学分析。结果：6月龄组、12月龄组和18月龄组大鼠心肌中Cx43含量逐渐降低（P〈0．01），3组大鼠心率呈下降趋势，Cx43与心率之间具有相关性（P〈0．01）。结论：随着大鼠衰老，脏腑组织器官失养，功能低下，代谢失常，心肌Cx43含量及心率增龄性下降，心肌Cx43增龄性降低亦减缓了大鼠心率。

英文摘要：

Objective ：Through the experiment to observe the characteristics of myocardial Cx43 and heart rate in rats with＇ age change, and the relationship between them： MethOds ：30 rats were divided into three groups, the 6 -month old group, 12 -month old group and 18 - month old group, each group had 10 rats. Determination of the content of Cx43 was made by immunohistochem- ieal method and we recorded the heart rate of each rats. Statistical analysis of experimental data was made by SPSS19.0. Results： The content of Cx43 in myocardium in the rats of 6 -month old group,12 -month old group and 18 -month old group decreased with aging（P 〈 0.01 ）. The heart rate of rats in the three groups was decreased and Cx43 had correlation with heart rate （P 〈 0. 01 ）. Conclusion：With the aging of rats, organs failure, hypofunction, metabolic disorder and the Cx43 content in myocardium and heart rate decline and myocardial Cx43 age - related decrease also slows the heart rate of the rat.