中文摘要：

空间微生物制药是将代谢物可用于制药工艺的微生物送到太空,利用太空特殊的环境诱变作用,使微生物产生变异,并在其返回地面后进行培育、筛选,最终获得生产性能优良的微生物菌种的育种新技术。目前在空间制药研究方面国外以美国居多,我国的空间生命科学研究在制药领域特别是生物制药领域刚刚起步。由于空间环境的诱变作用使细菌产生的有益变异多、变异幅度大、变异稳定性好,在未来生物制药领域具有广阔的应用前景。但目前尚无法控制变异的方向,只能是任其发展,并且只有在样品返回地面后通过大规模筛选才能得到有益突变菌株,筛选效率不够高,如何利用太空资源进行定向甚至定点突变,以及如何高效率筛选有益突变株,仍需要不断的探索。

英文摘要：

Space microbial pharmaceutics is a new microbial breed technology, primarily utilizing the mutagenesis effect of the special space environment on the bacteria whose metabolite could be used in the pharmaceutical process to produce mutant colonies with high quality and/or quantity, which were picked out with cultivation and screening experiments after the bacteria returned to the ground. At present, most studies in this field were performed in America. In China, it＇s still in the initial stage. Because space breeding has advantages like more beneficial mutation, large variation and good stability, space microbial pharmaceutics will share bright future in the future biopharmaceutics. However,it is still unable to control the direction of variation, only letting it go, and the efficiency of beneficial mutation strain obtaining is still low, as large-scale screening experiments are essential after it returned to the ground. So perennial efforts are needed to make use of space resources for directed mutagenesis and to gain beneficial mutation strain with high efficiency.