中文摘要：

观察 Dachengqi 煎的效果的目的(澶ф壙姘旀堡， DCQD ) 在在伤寒的网络的词法变化上， Cajal (国际计算中心) 的神经空隙的房间弄平伤寒的肌肉房间(SMC ) 在有多重机关机能障碍症候群(MODS ) 的老鼠的深肌肉发达的丛(DMP ) 。称 200 ～ 250 g 的两性的 100 只 Wistar 老鼠随机被划分成控制组， MODS 组，和 DCQD 组的方法。在肠的 DMP 的伤寒 nerve-ICC-SMC 网络的词法变化用 c 工具包和小囊的醋胆素 transporter/neuronal 被观察有整个山的准备技术，共焦的激光扫描显微镜学，和电子显微镜学的氮的氧化物 synthase immunohistochemical 双 staining。结果与在在 MODS 的肠的 DMP (ICC-DMP ) 的 cholinergic/nitrergic 神经和国际计算中心的控制组，分发和密度相比组织显著地被减少(P < 0.01 ) ，并且胆碱能的 nerve-ICC-SMC 的网络被破坏；并且 ICC-DMP，伤寒神经，和 SMC 的 ultrastructural 特征严重地被损坏。在有 DCQD 的处理以后，在伤寒 nerve-ICC-SMC 的网络的损坏显著地被恢复。与 MODS 组相比，在 DCQD 组的 cholinergic/nitrergic 神经和 ICC-DMP 的分发和密度显著地被增加(P < 0.01 ) ；并且 ultrastructural ICC-DMP 展示，伤寒神经，光滑的肌肉房间显著地被恢复。结论 DCQD 能在 MODS 改进胃肠的活动性。机制可能与在伤寒 nerve-ICC-SMC 的网络修理损坏的效果有关。关键词 Dachengqi 煎 - 多重器官机能障碍症候群 - Cajal 的空隙的细胞 - 光滑的肌肉细胞由中国(号码 30772860 和号码 30800382 ) 的国家自然科学基础支持了的伤寒神经

英文摘要：

Objective： To observe the effects of Dachengqi Decoction （大承气汤, DCQD） on morphological changes in the network of enteric nerve-interstitial cells of Cajal （ICCs）-smooth muscle cells （SMC） of enteric deep muscular plexuses （DMP） in the rats with multiple organ dysfunction syndrome （MODS）. Methods： One hundred Wistar rats of both sexes weighing 200 to 250 g were randomly divided into the control group, MODS group, and DCQD group. The morphologic changes of enteric nerve-ICC-SMC network in the DMP of intestine was observed using c-Kit and vesicular acetylcholine transporter/neuronal nitric oxide synthase immunohistochemical double-staining with whole-mount preparation technique, confocal laser scanning microscopy, and electron microscopy. Results： Compared with the control group, the distribution and densities of cholinergic/nitrergic nerves and ICC in the DMP （ICC-DMP） of intestine in the MODS group were significantly decreased （P0.01）, and the network of cholinergic nerve-ICC-SMC was disrupted; and the ultrastructural features of ICC-DMP, enteric nerve, and SMC were severely damaged. After treatment with DCQD, the damage in the network of enteric nerve-ICC-SMC was significantly recovered. Compared with the MODS group, the distribution and densities of cholinergic/nitrergic nerves and ICC-DMP in the DCQD group were significantly increased （P0.01）; and the ultrastructural features of ICC-DMP, enteric nerve, smooth muscle cells were significantly recovered. Conclusions： DCQD can improve the gastrointestinal motility in MODS. The mechanism may be related to the effect of repairing the damages in the network of enteric nerve-ICC-SMC.