中文摘要：

客观：描绘在之间的关系 STAT1 和 Survivinexpression，和在他们和淋巴节点转移之间的关系，在完整的淋巴节点的侵略和预后的深度检查了中国的胃的癌症病人。方法：在 1988 和 2003 之间的药品解剖的标本从 JianghanUniversity 的隶属于的医院被收集。所有 140 个病人有完全的考试数据。所有淋巴结被清除胖方法发现。打断的连续剧染色 andimmunohistochemical 方法的 4 μ m 节，平淡的苏木精和曙红被用来检测淋巴节点转移。胃的癌症 tissuemicroarray 被形成，在胃的癌症的 survivin 和 STAT1 的表示是检测 byimmunohistochemical 方法。所有数据多用枪兵等级相关分析， Kaplan-Meyer 木头等级方法和考克斯被处理变量分析(社会科学统计套装软体 12.0 软件) 。结果：在微数组构造了的 140gastric 癌症织物之中， 110 能被使用(利用率是 78.6%) 。7079lymph 节点在 110 种情况(64.4/case ) 中被发现。转移在 89 种情况和 1679 个淋巴节点中被发现。survivin 和 STAT1 的积极表示率是 52.7%(58/110 ) 并且 40%(44/110 ) 分别地。在 STAT1 表示和 survivinexpression 之间有重要否定关联(r=-0.19， P=0.04 ) 。STAT1 表示与侵略的深度有否定关联(r=-0.21， P=0.04 ) 。Survivin 表示与 UICC N 舞台有否定关联(r=-0.24， P=0.01 ) 并且组织学的分类(r=-0.21， P=0.03 ) 由枪兵等级相关分析。Butsurvivin 和 STAT1 表示没与预后被联系。在淋巴节点转移和预后之间的重要关联被考克斯多表明变量分析(χ ~ 2=4.85， P=0.028 ) 。结论：STAT1 在胃的癌症与 survivin 表示有否定关联。他们俩没在胃的癌症与预后有关联。STAT1 表示能是一个分子的标记预言先进胃的癌症和 survivin 在胃的癌症的淋巴节点转移的一个分子的标记。UICC N 舞台是在在中国的胃的 caner 的最重要的预示的因素。

英文摘要：

Objective： To characterize the relationship between STAT1 and Survivin expression, and the relationship between them and lymph node metastasis, depth of invasion and prognosis in full lymph node examined gastric cancer patients of China. Methods： Specimens of curative dissection between 1988 and 2003 were collected from the affiliated hospital of Jianghan University. All 140 patients had complete examination data. All lymph nodes were found by clearing fat method. The interrupted serial 4 μm sections, routine hematoxylin and eosin staining and immunohistochemical methods were used to detect the lymph node metastases. Gastric cancer tissue microarray was formed and the expression of survivin and STAT1 in gastric cancer was detected by immunohistochemical method. All data were processed using Spearman rank correlation analysis, Kaplan-Meyer Log-rank method and Cox multivariate analysis （SPSS 12.0 software）. Results： Among 140 gastric cancer tissue microarrays constructed, 110 could be used （utilization rate was 78.6%）. 7079 lymph nodes were found in 110 cases （64.4/case）. Metastases were found in 89 cases and 1679 lymph nodes. Positive expression rate of survivin and STAT1 was 52.7% （58/110） and 40% （44/110） respectively. There was a significant negative correlation between STAT1 expression and survivin expression （r=-0.19, P=0.04）. STAT1 expression had a negative correlation with depth of invasion （r=0.21, P=0.04）. Survivin expression had a negative correlation with UICC N stage （r=-0.24, P=0.01） and histological classification （r=-0.21, P=0.03） by Spearman rank correlation analysis. But survivin and STAT1 expression was not related with prognosis. A significant correlation between lymph node metastasis and prognosis was demonstrated by Cox multivariate analysis （X^2=4.85, P=0.028）. Conclusion： STAT1 has a negative correlation with survivin expression in gastric cancer. Both of them have no correlation with prognosis in gastric cancer. STAT1 expression can be a mole