中文摘要：

目的系统分析和评价多发性肌炎／皮肌炎合并间质性肺疾病的预测因素，为临床早期诊治提供循证依据。方法利用Meta分析方法分析国内外23篇关于多发性肌炎（PM）／皮肌炎合并间质性肺疾病（ILD）预测因素的文献，应用Rev—Man4．2分析软件进行异质性和敏感性分析，并根据异质性检验结果，采用固定效应或随机效应模型计算合并比值比（OR值）和95％可信区间（95％CI）。应用Stata10．0软件进行发表偏倚识别。结果对关节炎，关节痛、发热、抗Jo-1抗体阳性、抗核抗体阳性、Gottron征、吞咽困难、雷诺现象共7个因素进行Meta分析，结果显示与PM／皮肌炎合并ILD存在关联性的因素及其OR值和95％C1分别是：抗Jo-1抗体阳性6．94（4．74-10．16）、发热4．90（3．82～6．29）、关节炎，关节痛3．93（3．21～4．80）、Gottron征2．52（1．24-5．14）和抗核抗体阳性1．59（1．02～2．47）。而与PM／皮肌炎合并ILD无关联性的因素及其OR值和95％C1分别为雷诺现象1．40（0．97～2．01）和吞咽困难1．21（0．94～1．56）。结论抗Jo-1抗体阳性、发热、关节炎／痛、Gottron征和抗核抗体阳性可作为PM／皮肌炎合并ILD的主要预测因素。

英文摘要：

Objective To systematically review and evaluate the predictive factors of interstitial lung disease （ILD） in patients with polymyositis and dermatomyositis （PM/DM）, and provide evidence for early clinical diagnosis. Methods The predictive factors of PM/DM-related ILD from 23 published papers were analyzed by Meta-analysis. Analysis of heterogeneity and sensitivity were performed and pooled odds ratio （OR） with 95% confidence interval （95%CI） were calculated using either fixed or random effects models by Rev-Man 4.2 software. Stata 10.0 software was used to identify publication bias. Results Meta-analysis was performed to analyze seven factors including anti-Jo-1 antibody, fever, arthritis/arthralgia, Gottron＇s sign, antinuclear antibody （ANA）, and dysphagia Raynaud＇s phenomenon. Factors correlated with ILD in patients with PM/DM and their OR values and 95%CI were as follows： the presence of anti-Jo-1 antibody 6.94 （4.74- 10.16）, fever 4.90 （3.82-6.29）, arthritis/arthralgia 3.93 （3.21 -4.80）, Gottron＇ s sign 2.52 （ 1.24 ~5.14）, and the presence of ANA 1.59（1.02-2.47）. Raynaud＇s phenomenon and dysphagia were not correlated with ILD in patients with PM/DM with OR values and 95%CI as 1.40 （0.97-2.01）, and 1.21 （0.94-1.56） respectively. Conclusion The presence of anti-Jo-1 antibody, fever, arthritis/arthralgia, Gottron＇s sign and ANA are major predictive factors for ILD in patients with PM/DM.