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蚕沙叶绿素锌配合物对DNA的光断裂作用
  • 期刊名称：高等学校化学学报，31 (3)，442-446, 2010
  • 时间：0
  • 分类：O614.24[理学—无机化学;理学—化学]
  • 作者机构：[1]华南理工大学化学与化工学院,广州510641, [2]中山大学化学与化学工程学院,广州510275
  • 相关基金：国家自然科学基金（批准号：20771039 20871122 20971046）资助
  • 相关项目：端粒酶抑制剂：钌配合物与G-四链体DNA的相互作用研究
关键词： 蚕沙, 叶绿素, DNA, 光断裂, Chlorophyll, Silkworm faeces, DNA, Photocleavage
中文摘要：

利用从蚕沙中提取的叶绿素（CHL）制得了锌叶绿素（Zn-CHL）配合物.采用紫外-可见光谱、CD光谱和黏度法研究了Zn-CHL与小牛胸腺DNA（ct-DNA）的相互作用,并采用琼脂糖凝胶电泳研究了光照条件下Zn-CHL对pBR322 DNA的切割能力.结果表明,Zn-CHL与ct-DNA的作用方式属于外部结合模式,其结合常数为2.32×105L/mol,Zn-CHL在可见光照射下具有切割DNA的能力.

英文摘要：

Zinc chlorophyll（Zn-CHL） complex was prepared using chlorophyll extacted from silkworm faeces.Relative viscosity,UV-Visible and CD spectra were used to study the interaction between Zn-CHL and ct-DNA.Agarose gel electrophoresis was also carried out to investigate the photocleavage ability of Zn-CHL to pBR 322 DNA.The results suggested that the binding mode of Zn-CHL and ct-DNA was outside binding,the binding constant was 2.32×105 L/mol.Agarose gel electrophoresis picture showed that Zn-CHL could induce DNA cleavage upon irradiation.

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