中文摘要：

小牛胸腺 DNA (CT DNA ) 和水溶性的锰 corrole 的相互作用， 5,10,15-tris (4-carboxyphenyl ) corrolatomanganese (III )(MnIIITCPC ) 被吸收系列，荧光系列和 CD 系列，以及由粘性大小学习了。结果表明这锰 corrole 与 4.67 敲 ? 景的内在的有约束力的经常的 Kb 经由一个外面的沟绑定模式把 DNA 绑在 CT 吗？

英文摘要：

The interaction of calf thymus DNA （CT DNA） and water-soluble manganese corrole, 5,10,15-tris（4-carboxyphenyl）corrolatomanganese（Ⅲ） （MnuTCPC） has been studied by absorption spectra, fluorescence spectra and CD spectra, as well as by viscosity measurements. Results revealed that this manganese corrole binds to CT DNA via an outside groove binding mode with intrinsic binding constant Ku of 4.67 × 104 Lomol L DNA cleavage activities of MnmTCPC in the presence of various oxidants were also investigated, MnmTCPC can cleave the supercoiled plas- mid pBR322 DNA to both nicked and linear form in the presence of hydrogen peroxide or tert-BuOOH, while no nuclease activity was observed by using KHSO5 as oxidant. Inhibitor tests revealed that hydroxyl radicals or singlet oxygen was not involved in MnTCPC mediated DNA oxidative cleavage. It is suggested that （oxo）manganese（V） corrole is the possibly active intermediate in this oxidative cleavage reactions.