中文摘要：

目的：探讨血清亮氨酸氨基肽酶（LAP）在异常妊娠妇女不同时期的变化规律及临床意义。方法：采用速率法分别检测2012年10月-2014年10月收治的早期妊娠妇女60例（早期组,包括异位妊娠22例和正常妊娠38例）、中期妊娠妇女60例（中期组,包括先兆流产24例和正常妊娠36例）、晚期妊娠妇女60例（晚期组,包括子痫前期18例、肝内胆汁淤积症21例和正常妊娠21例）,检测以上各组研究对象的LAP及相关指标并进行比较。结果：妊娠早期,异位妊娠组血清LAP水平显著低于正常妊娠组（P〈0.05）;正常妊娠组与异位妊娠组甘胆酸（CG）、碱性磷酸酶（ALP）、α-L-岩藻糖苷酶（AFU）、丙氨酸氨基转移酶（ALT）和天门冬酸氨基转移酶（AST）水平比较差异无统计学意义（P〉0.05）。妊娠中期,先兆流产组与正常妊娠组LAP、CG、ALP、AFU、ALT和AST水平比较差异无统计学意义（P〉0.05）。妊娠晚期,子痫前期组与正常妊娠组LAP、CG、ALP、AFU、ALT和AST水平比较差异无统计学意义（P〉0.05）,肝内胆汁淤积症组的LAP、CG、ALP、AFU、ALT和AST水平均显著高于子痫前期组和正常妊娠组（P〈0.05）。结论：妊娠过程中对妊娠妇女血清LAP进行连续监测可以及时发现妊娠过程中的异常情况,对胎儿正常发育具有积极作用。

英文摘要：

Objective： To explore the change regularity of serum leucine aminopeptidase（ LAP） in abnormal pregnant women during different periods and the clinical significance. Methods： From October 2012 to October 2014,velocity method was used to detect LAP and related indexes among 60 early pregnant women（ early pregnancy group,including 22 women with ectopic pregnancy and 38 normal pregnant women）,60 mid-pregnant women（ mid-pregnancy group,including 24 women with threatened abortion and 36 normal pregnant women）,and 60 late pregnant women（ late pregnancy group,including 18 women with preeclampsia,21 women with intrahepatic cholestasis of pregnancy,and 21 normal pregnant women）,then the results were compared. Results： Among the early pregnant women,serum LAP level in ectopic pregnancy group was statistically significantly lower than that in normal pregnancy group（ P〈0. 05）; there was no statistically significant difference in the levels of cholyglycine（ CG）,alkaline phosphatase（ ALP）,α-L-fucosidase（ AFU）,alanine aminotransferase（ ALT）,and aspartate aminotransferase（ AST） between normal pregnancy group and ectopic pregnancy group（ P〉0. 05）. Among the midpregnant women,there was no statistically significant difference in the levels of LAP,CG,ALP,AFU,ALT,and AST between threatened abortion group and normal pregnancy group（ P〉0. 05）. Among the late pregnant women,there was no statistically significant difference in the levels of LAP,CG,ALP,AFU,ALT,and AST between preeclampsia group and normal pregnancy group（ P〉 0. 05）; the levels of LAP,CG,ALP,AFU,ALT,and AST in intrahepatic cholestasis of pregnancy group were statistically significantly higher than those in preeclampsia group and normal pregnancy group（ P〈0. 05）. Conclusion： Continuous monitoring of serum LAP among pregnant women can timely find abnormalities during pregnancy,which has active impact on normal development of fetuses.