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Mathematical models of canine right and left atria cardiomyocytes
  • ISSN号:1673-1581
  • 期刊名称:《浙江大学学报:B卷英文版》
  • 时间:0
  • 分类:Q27[生物学—细胞生物学] R54[医药卫生—心血管疾病;医药卫生—临床医学;医药卫生—内科学]
  • 作者机构:[1]Key Laboratory of Biomedical Engineering of Ministry of Education Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, China, [2]Center of Arrhythmia Diagnosis and Treatment, Cardiovascular Institute & Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100037, China, [3]Biological Physics Group, School of Physics and Astronomy, The University of Manchester, Manchester M13 9PL, UK
  • 相关基金:Project supported by the National Basic Research Program (973) of China (No. 2007CB512100), the National High-Yech R & D Program (863) of China (No. 2006AA02Z307), and the National Natural Science Foundation of China (No. 30570484)
中文摘要:

这研究的目的对正确正厅和左正厅造犬的离子的水流的二个数学模型特定。犬的左正厅数学模型第一用离子的水流的最近可得到的试验性的数据从 Ramirez-Nattel-Courtemanche (RNC ) 模型被修改并且进一步基于我们的自己的试验性的数据被开发。正确正厅的一个模型然后被考虑正确正厅和左正厅之间的差别造。二个发达模型很好在行动潜力形态学,率依赖,和行动潜力上复制了试验性的数据持续时间归还。他们为调查位于犬的地区性的行动潜力的异质下面的机制是有用的并且在不久的将来将帮助整个心刺激繁殖和心脏的心律不齐的模拟。关键词 Atrial 纤维性颤动-犬的正厅-数学模型-行动潜在的持续时间归还 CLC 数字 Q27 -中国(号码 2007CB512100 )的国家基本研究程序( 973 )支持的 R54 工程,国家高技术 R 与 D 编程序( 863 )中国(号码 2006AA02Z307 ),并且中国(号码 30570484 )的国家自然科学基础

英文摘要:

The aim of this study is to build two mathematical models of canine ionic currents specific to right atria and left atria.The canine left atria mathematical model was firstly modified from the Ramirez-Nattel-Courtemanche(RNC) model using the recently available experimental data of ionic currents and was further developed based on our own experimental data.A model of right atria was then built by considering the differences between right atria and left atria.The two developed models well reproduced the experimental data on action potential morphology,the rate dependence,and action potential duration restitution.They are useful for investigating the mechanisms underlying the het-erogeneity of canine regional action potentials and would help the simulation of whole heart excitation propagation and cardiac arrhythmia in the near future.

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期刊信息
  • 《浙江大学学报:B卷英文版》
  • 中国科技核心期刊
  • 主管单位:
  • 主办单位:浙江大学
  • 主编:
  • 地址:杭州玉古路20号,浙江大学学报《英文版》编辑部
  • 邮编:310027
  • 邮箱:jzus@zju.edu.cn
  • 电话:0571-87952276 87952331
  • 国际标准刊号:ISSN:1673-1581
  • 国内统一刊号:ISSN:33-1356/Q
  • 邮发代号:
  • 获奖情况:
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  • 被引量:323