中文摘要：

目的：探讨近红外光谱技术（NIRS）用于创伤性脑水肿活体实时监测的可行性。方法：采用Feeney＇s自由落体撞击法建立急性局灶性脑挫裂伤模型,以NIRS实时监测静脉注入脱水剂后脑组织优化散射系数（μs＇）的变化情况。结果：脑组织受到创伤后水肿即开始发生,μs＇值呈抛物线形上升,但伤侧水肿的程度和速度明显大于健侧,1 h后两者之间差异具有统计学意义（P〈0.05）;注入脱水剂后μs＇值呈U形变化,先迅速降低,达到并维持一个平台期2.5～3.0 h,然后逐渐回升,于注射后4.5～5.5 h回复到注射前水平;相同渗透浓度的高渗盐水与甘露醇相比,起效更快,发挥最大效用所需要的时间更短,维持时间更长。结论：μs＇是监测创伤性脑水肿的良好指标,能够较好地反映脑组织水肿程度以及脱水剂的作用效果。NIRS可以用于创伤性脑水肿的实时监测。

英文摘要：

Objective： To investigate the feasibility of real-time monitoring traumatic brain edema in vivo using near-infrared spectroscopy（NIRS） technology.Methods： Acute regional brain trauma models were applied according to Feeney＇s apparatus.The changes of reduced scattering coefficient（μs＇） value in brain was real-time monitored by NIRS after injecting the dehydration drugs.Results： Brain edema was found after trauma.The curves of μs＇ value showed a parabola pattern both in the injured side and the healthy side,however,the value of μs＇ rose faster and greater in the former.The difference between the two sides was found statistically 1 h later（P0.05）.The curves of μs＇ value had a U-shaped variation after injecting the dehydration to the rats： first,it declined rapidly;then achieved a plateau and maintained about 2.5-3 h;finally,recovered to the level of before injection gradually 4.5-5.5 h later.Compare to the mannitol with the same osmasis,hypertonic saline had an earlier,faster and prolonged effect.Conclusion： The value of μs＇ is a good indicator for monitoring traumatic brain edema,which reflects the degree of brain edema and the effect of dehydration drugs.NIRS is used in real-time monitoring of the development of traumatic brain edema in vivo.