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中文摘要：
Rex-1和Oct4是在多能性细胞中特异表达的转录因子，而Rex-1的生物学功能及其调控胚胎干细胞（ES细胞）多能性和分化能力的机制尚不清楚。实验探讨了Rex-1和Oct4的相互关系，利用免疫荧光实验和免疫共沉淀实验证明了Rex-1和Octd两种蛋白共同定位于细胞核中，证明二者之间有直接的相互作用。进一步的活性分析表明Rex-1能够抑制Oct4的转录激活活性。这些数据提供了一种新的调控Oct4活性的机制。
英文摘要：
The transcription factor Rex-1 has long been used as an ES cell and potential to regulate ES cell pluripotency and self-renewal remains elusive. colocalized with Oct4 in the nucleus by immunofluorescent staining and the ph marker but its biological function The results showed that Rex-1 is ysical interaction and Oct4 was proved by immunoprecipitation. Furthermore, the results were also indicated by Oct4, Rex-1 can inhibit Oct4 transcriptional activity. In all, the data suggested a new mechani Oct4 activity by Rex-1 in ES cells.
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