中文摘要：

目的探讨胃癌组织Tiam1在胃癌的发生、发展过程中的作用。方法运用免疫组化法结合组织芯片技术联合检测189例胃癌、54例癌旁、30例正常组织及59例对应的淋巴结中的Tiam1蛋白表达情况。结果 Tiam1蛋白在胃癌组织、癌旁组织及正常胃黏膜的表达阳性率分别为85.7%、74.1%和16.7%,比较差异有统计学意义（χ2=67.448,P〈0.001）。Tiam1蛋白表达与淋巴结转移、分化程度及浸润深度密切相关（P〈0.05）。胃癌原发灶Tiam1蛋白表达阳性率（85.0%）高于相对应的淋巴结转移灶（65.0%）（χ2=4.267,P〈0.05）。Tiam1蛋白表达阳性具有显著的生存危险,是独立的生存期预测因子。结论 Tiam1蛋白表达与临床病理特征密切相关,其表达方式与患者的生存期密切相关,可作为独立的生存期预测因子。

英文摘要：

Objective To investigate effect of Tiam1 in gastric cancer tissue in occurrence and progress of gastric cancer. Methods Immunohistochemistry combined with tissue microarray were applied in detection of Tiam1 expression in 189 gastric cancer tissue cases, 54 adjacent tissue cases, 30 normal tissue cases, and 59 corresponding lymphonodus. Results The positive rates of Tiam1 expression in gastric cancer tissue, adjacent tissue, and normal gastric mucosa were respectively 85.7%, 74.1% and 16.7%, and their difference had statistical significance（χ2=67.448, P〈0.001）. Tiam1 expression was closely related with lymphatic metastasis, differentiated degree, and infiltration depth（P〈0.05）. The positive rate of primary Tiam1 expression in gastric cancer（85.0%） was higher than corresponding lymphatic metastasis（65.0%）（χ2=4.267, P〈0.05）. Positive Tiam1 expression showed remarkably survival risk, and that was an independent survival predictor. Conclusion Tiam1 expression is closely related with clinicopathologic characteristics. Its expression way has close correlation with survival time of patients, and it can be taken as the independent survival predictor.