中文摘要：

目前，世界范围内有近2亿人通过饮水和饮食暴露于具有毒性危险的砷，慢性砷中毒已经成为严重威胁人类健康的全球性的公共卫生问题。砷作为确认的人类致癌物，其毒性作用具体分子和细胞机制尚不清楚，氧化应激是目前被广泛接受与研究的砷毒性作用机制。本文主要综述了砷诱发活性氧的生成、相关生物标志和砷对抗氧化酶以及抗氧化防御系统作用的相关研究进展。

英文摘要：

Currently ,it is estimated that more than 200 million people are at risk of toxic arsenic exposure from groundwater and food contamination . Arsenicosis is a serious and widespread global public health problem . However ,the exact molecular and cellular mechanisms involved in arsenic toxicity remain unclear .Oxidative stress is currently the most widely accepted and studied mechanism of arsenic toxicity .This review updates recent advances in generation of arsenic‐induced reactive oxygen species ,its relevant biomarkers ,the effects of arsenic on enzyme activities and the cellular defense mechanism .