中文摘要：

目的：观察逍遥散加味的温阳解郁不同配伍组方的抗抑郁效果。方法：将小鼠分为正常对照组、逍遥散组、燮神方组、加活血化痰方组、加温阳方组、加味药组,以强迫游泳实验作为观察指标,分别观察小鼠第3d、5d、7d小鼠强迫游泳不动时间,在此基础上,进一步观察燮神方组成中逍遥散各减一味药所组复方对小鼠强迫游泳不动时间的影响。结果：逍遥散加温阳解郁方第7d强迫游泳不动时间明显缩短（P〈0.05）,减白芍、薄荷、白术则强迫游泳不动时间显著延长,减柴胡、茯苓、甘草、当归对强迫游泳不动时间的影响不明显。结论：逍遥散加温阳解郁复方抗抑郁作用强于其他配伍组方,治疗7d可达明显效果,方中白芍、薄荷、白术的药效较为关键,单纯温阳解郁药无明显抗抑郁效果。

英文摘要：

Objective：To observe antidepressant effect of compound prescription of warming yang with regulating qi which contain Xiaoyao powder and its different modified combinations. Methods ： Mice were randomly divided into controlled group,Xiaoyao powder group（xiaoyaosan）,Xie shenfang group plus promoting blood circulation and resolving phlegm group（plus ROBP）, plus warming yang group（plus WY）, and plus drugs group（plus Drugs）. Then observe the immobility time of mice in forced swimming test respectively on the third day, fifth day and seventh day. Based on the above experiments, further observe the effect of different prescription respectively with one subtracted drug. Results： The immobility time of Xieshenfang was significantly reduced on the seventh day（ P〈0.05）and the immobility time of minus radix paeoniae alba group,minus mint group,minus Baizhu group were significantly extended, but there was no obvious effect in minus bupleurum chinense group,minus poria cocos group,minus liquorice group,and minus angelica sinensis group. Conclusion： Xiaoyao powder plus Warming yang and regulate qi had more effectiveness than other prescriptions and continuous treatment up to seventh day could show noticeable resuits,of which radix paeoniae alba, mint, baizhu are the key drugs in prescription. Warming yang with regulating qi drugs without Xiaoyao powder has no antidepressant effect.