中文摘要：

虽然血管生成素发现于1985年,但由于其性质上的特殊及研究条件的限制,人类对其功能的了解进展缓慢.浙江大学血管生成素研究组建立于2001年,主要从蛋白质相互作用、基因转录调控、RNA代谢等层面研究血管生成素的功能机制,发现该蛋白能够与卵泡抑素、磷脂混杂酶1等蛋白质相互作用而细调r RNA的转录水平;在RNA转录中发挥表观遗传修饰调控因子作用;通过与细胞骨架相关蛋白的相互作用而促进细胞迁移;miR-409-3p通过直接靶向下调该蛋白的表达而发挥抑癌基因的作用.同时,在模式生物斑马鱼中揭示了血管生成素同源基因对胚胎早期发育的影响.本文全面回顾了我们14年来在血管生成素方面的研究进展,探讨了当前研究中存在的问题,并展望了未来的发展方向.

英文摘要：

Angiogenin （ANG） was identified in 1985. Limited by its unique characteristics and available research technology, the understanding on its physiological and pathological functions progresses slowly. ANG research in Zhejiang University has started since 2001, and focuses on its functions and mechanisms of action through protein-protein interactions, gene transcription regulation, and RNA metabolism. We found that ANG interacts with follistatin, phospholipid scramblase 1 or other proteins to achieve fine regulation of rRNA transcription level, plays an epigenetic modification regulator in RNA transcription, interacts with cytoskeleton-associated proteins to facilitate cell migration, and miR-409-3p plays as a tumor suppressor by directly targeting and down-regulating ANG expression. Meanwhile, we also revealed that ANG homologous gene affects the early development of zebrafish embryo. This paper comprehensively reviewed our research progress on ANG in the past 14 years, discussed problems in current study, and presented the future research direction.