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Overexpression of Hdac6 enhances resistance to virus infection in embryonic stem cells and in mice
  • ISSN号:1673-8527
  • 期刊名称:《遗传学报:英文版》
  • 时间:0
  • 分类:Q813[生物学—生物工程] S858.291[农业科学—临床兽医学;农业科学—兽医学;农业科学—畜牧兽医]
  • 作者机构:[1]State Key Laboratory of Medicinal Chemical Biology, Collaborative Innovation Center for Bietherapy, Department of Genetics and Cell Biology, College of Life Sciences, Nankai University, Tianjin 300071. China, [2]State Key Laboratory of Veterinary Biotechnology, Harbin Veter- inary Research Institute, Chinese Academy of Agricultural Sci- ences, Harbin 150001, China, [3]State Key Laboratory for Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing 100193, China, [4]College of Animal Science and Veterinary Medicine, Jilin Univer- sity, Changchun 130062, China
  • 相关基金:We thank Drs. Xiaohong Zhang, Zhonghua Liu, and Wentao Qiao for help and discussion. This work was supported by the Ministry of Agriculture of China Transgenic Special Program (2009ZX08006-010B, 2009ZX08006-001B), the National Basic Research Program (973 Program) (Nos. 2011CBA01002 and 2009CB941000), the National Science and Technology Major Project of China (2012ZX10001-006), and the Natural Science Foundation of Tianjin, China (No. 14JCYBJC23600). Dekun Wang, Qingwen Meng, Lihong Huo, Meng Yang, Lingling Wang, Xinyu Chen, Jianchao Wang, Zhiguo Li, Xiaoying Ye, Na Liu, Qiuyan Li, Zhen Dai, Hongsheng Ouyang, Ning Li, Jun Zhou, Lingyi Chen, and Lin Liu declare no conflict of interest. All institutional and national guidelines for the care and use of laboratory animals were followed.
中文摘要:

亲爱的编辑,

英文摘要:

Dear Editor Histone deacetylase 6 (Hdac6) is a mostly cytoplasmic class II HDAC. Many proteins have been identified as substrates of Hdac6. Among them, the most well characterized sub- strate of Hdac6 is a-tubulin. Through deacetylating acety- lated lysine 40 in a-tubulin, Hdac6 modulates the acetylation of microtubules (Hubbert et al., 2002).

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期刊信息
  • 《遗传学报:英文版》
  • 北大核心期刊(2004版)
  • 主管单位:中国科学院
  • 主办单位:中国科学院遗传与发育生物学研究所 中国遗传学会
  • 主编:薛勇彪
  • 地址:北京市安定门外大屯路中科院遗传发育所
  • 邮编:100101
  • 邮箱:ycxb@genetics.ac.cn
  • 电话:010-64807669
  • 国际标准刊号:ISSN:1673-8527
  • 国内统一刊号:ISSN:11-5450/R
  • 邮发代号:2-819
  • 获奖情况:
  • 1996年获中科院优秀期刊二等奖,1997年获全国优秀期刊三等奖,200年获中科院优秀期刊二等奖
  • 国内外数据库收录:
  • 俄罗斯文摘杂志,美国化学文摘(网络版),英国农业与生物科学研究中心文摘,波兰哥白尼索引,荷兰文摘与引文数据库,荷兰医学文摘,美国生物医学检索系统,美国科学引文索引(扩展库),美国生物科学数据库,英国动物学记录,日本日本科学技术振兴机构数据库,中国中国科技核心期刊,中国北大核心期刊(2004版),中国北大核心期刊(2000版)
  • 被引量:17519