中文摘要：

钠氢交换蛋白是一类存在于细胞膜表面的离子转运泵蛋白家族。它负责将细胞内H＋与胞外Na＋按照1∶1的比例进行交换来调控细胞内pH的动态平衡,影响细胞的容积、运动、分化、凋亡和营养吸收,从而参与许多复杂的生理和病理过程。迄今为止,钠氢交换蛋白家族已发现有9个成员,各亚型间具有结构相似性和组织分布特异性。深入研究NHE的结构、功能及基因表达调控,将为人和哺乳动物的营养生理、疾病治疗提供新的思路和方法。

英文摘要：

In mammalian eukaryotic cells, the Na^＋/H^＋ exchanger （NHE） is a family of membrane protein that regulates ions fluxes across membranes, which regulates intracellular pH homeostasis by extruding one intracellular proton in exchange for one extracellular sodium. It also plays a key role in the cellular functions including volume regulation, migration, proliferation, differentiation and apoptosis, which involved in a variety of complex physiological and pathological events. To date, The NHE family consists of 9 known isoforms, NHE 1-NHE9, which have homology structure and different tissue distribution. To study the topology, function and gene expression of NHE, it may provide a new way on nutrition regulation, immune enhancement and treating for diseases of human and animal.