中文摘要：

目的：了解脑胶质瘤生长部位、手术方式、病理分级和术后治疗对患者术后生存时间的影响。方法：对第三军医大学西南医院2000年7月～2007年5月间经手术治疗的脑胶质细胞瘤患者中56倒进行随访，分析肿瘤生长部位、手术切除程度、病理分级和术后治疗与患者木后生存时间的关系。结果：本组病例肿瘤位于大脑半球者48例，术后1年生存率和3年生存率分别为43.8％和12．5％，位于小脑半球者6倒，术后1年生存率和3年生存率分别3为100％和66．7％，差异显著。、肿瘤达肉眼全切的患者1年和5年生存率最高，分别为61．1％和38．9％，大部分切除者次之，分别为59．1％和13．6％，而部分切除或活检或活检者最短，分剐为18．8％和0。Ⅰ～Ⅱ星形胶质细胞瘤术后1年和5年生存率分别为68．8％和28．1％，而Ⅲ～Ⅳ级者分别为13．6％和0。单纯手术、手术＋放疗、手术＋化疗、手术＋放疗＋化疗治疗的患者1年生存率分剐为16．7％、63．6％、71．4％、78．6％，5年生存率分别为0、27．3％、14．3％、42．9％。提示高级别胶质瘤患者的生存期短；小脑胶质细胞瘤患者术后生存时间明显高于大脑半球和丘脑区肿瘤；而手术切除肿瘤的彻底性仍是影响胶质瘤患者术后生存期最重要的因素，手术显微镜下肿瘤全切除和大部切除的术后生存时间明显优于部分切除或活检；术后放、化疗等综合治疗能显著延长患者的生存期。结论：手术方式、病理分级及术后治疗均能影响脑胶质细胞瘤患者术后生存时间，其中手术显微镜下全切和有效的术后治疗起决定作用。

英文摘要：

Objective： To evaluate the influence of site, origin, pathological grade of glioma, surgical method, and postoperative treatment on the survival of patients with glioma. Methods： A total of 56 patients with glioma proven by surgery and pathology treated in Southwest Hospital between July 2000 and May 2007 were followed up. Statistical analyses were performed to study the relationship between patient survival and pathological grade or origin of glioma. Results： Of all the subjects, 48 cases had gliomas located in the cerebral lobe. The postoperative 1- and 3-year survival rates for these patients were 43.8% and 12.5%, respectively. The postoperative 1- and 3-year survival rates were 100% and 66.7% in the 6 cases with tumors in the cerebellum. Patients who received total tumor removal using surgical microscopy had satisfactory 1- and 5-year survival rates of 61.1% and 38.9%, respectively. The 1- and 5-year survival rates were 61.1% and 38.9%, respectively, in patients who received sub-total resection and 18.8% and 0%, respectively, in patients who received partial resection or biopsy alone. The 1- and 5-year survival rates were 68.8% and 28.1% in patients with WHO grade Ⅰ or Ⅱ astrocytomas, and 13.6% and 0% in patients with WHO grade Ⅲ or Ⅳ astrocytomas. The 1- and 5- year survival rates were 16.7% and 63.6% in patients who received surgery alone, 71.4% and 78.6% in patients who were treated with surgery plus radiotherapy, 0% and 27.3% in patients who had surgery plus chemotherapy, and 14.3% and 42.9% in patients who received surgery plus radiotherapy and chemotherapy. These results suggest that patients with high grade glioma had a shorter survival time. Patients with glioma in the cerebellum had a longer survival time than those with glioma located in the cerebral hemisphere and thalamus. The extent of tumor excision is the most important modifiable factor for survival time. Patients with total tumor resection using surgical microscopy experienced a longer survival time than those patients who had p