中文摘要：

自我交叉连接氧化明胶的玻尿的 acid/ hydroxyapatite (GEL-OHA/HAp ) 没有使用任何有毒的化学药品，合成骨头代用品成功地在 situ 降水方法与一篇小说被准备跨连接器，并且包括水晶的阶段的元素的作文，表面形态学， crystallinity，和结构，它的描述被执行。以便评估它的相应表演，有 glutaraldehyde crosslinked gelatin/hydroxyapatite (GEL-Glu/ 幸运) 的比较合成详细被做。结果显示 nano 幸运雏晶同类地在 GEL-OHA/HAp 和 GEL-Glu/HAp composites 被驱散，并且在前者的幸运雏晶在后者比那些拿更大的粒子尺寸。机械性质测试在 GEL-OHA/HAp 的高紧张显示出可接受的机械力量合成。学习在 vitro 降级并且胀大证明二 composites 有类似的降级率和水吸收能力。由在 vitro 房间文化，这被发现了在 GEL-OHA/HAp 合成表演的房间比 GEL-Glu/HAp 上的房间潜在的更高的 proliferative 合成。与 GEL-Glu/HAp 相比合成， GEL-OHA/HAp 合成为无毒的骨头代用品的准备向优秀策略提供可接受的相应性质。

英文摘要：

Self-crosslinked gelatin-oxidized hyaluronic acid/hydroxyapatite（GEL-OHA/HAp） composite bone substitute was successfully prepared with a novel in situ precipitation method without using any toxic chemical cross-linkers,and its characterizations,including elemental composition,surface morphology,crystallinity,and structure of crystalline phase,were carried out. In order to evaluate its corresponding performances,comparisons with glutaraldehyde crosslinked gelatin/hydroxyapatite（GEL-Glu/HAp） composite were made in detail. The results indicate that nano-HAp crystallites are homogeneously dispersed in both GEL-OHA/HAp and GEL-Glu/HAp composites,and the HAp crystallites in the former take larger particle size than those in the latter. Mechanical property tests show the acceptable mechanical strength at high strain of GEL-OHA/HAp composite. Study of in vitro degradation and swelling demonstrate that the two composites have similar degradation rate and water absorption capability.By in vitro cell culture,it has been found out that the cells on the GEL-OHA/HAp composite show higher proliferative potential than the cells on the GEL-Glu/HAp composite. Compared with GEL-Glu/HAp composite,GEL-OHA/HAp composite provides an excellent strategy for preparation of non-toxic bone substitute with acceptable corresponding properties.