目的:探讨6岁以内孤独症儿童听性脑干反应(ABR)特征,评估孤独症儿童的听功能。方法回顾性分析6岁以内听力正常儿童(98例)及孤独症儿童(22例)的ABR测试结果,根据年龄将所有研究对象分为1~2岁组、2<~3岁组、3<~6岁组,对各组儿童的ABR反应阈、各波潜伏期及波间期进行统计学分析。结果1~2岁、2<~3岁及3<~6岁组正常听力儿童的ABR反应阈平均值分别为15.64±5.02、14.73±4.85及15.57±5.62 dB nHL ,孤独症儿童的ABR反应阈平均值分别为17.50±5.35、17.81±6.58及17.25±6.97 dB nHL ,各年龄组正常听力儿童与孤独症儿童之间ABR平均反应阈值差异无统计学意义(P>0.05)。在80 dB nHL 短声刺激下,各年龄段孤独症儿童的 ABR各波潜伏期或波间期平均值与正常听力儿童比较,差异均无统计学意义( P>0.05)。但是,22例孤独症儿童中,8例(36.36%,8/22)11耳(25.00%,11/44)出现ABR波潜伏期或波间期延长,其中波I、III、V 潜伏期及 I -III、III -V、I -V 波间期延长出现的几率分别为4.55%(2/44)、6.82%(3/44)、13.64%(6/44)、18.18%(8/44)、6.83%(3/44)及15.91%(7/44)。结论部分孤独症儿童存在不同程度的 ABR异常,且表现形式多样,以I-III波间期延长最常见。
Objective To investigate the characteristics of auditory brainstem response (ABR) in autistic children of 6 years or younger .Methods A total of 98 children with normal hearing and 22 autistic children were en‐rolled in this study .They were divided into 3 groups :1~2 years age group ,20 .05) .In 80 dB nHL click sound stimulus ,there was also no statistical difference in the values of peak latencies or interpeak intervals of ABR between normal hearing children and autistic children (P〉 0 .05) ,whereas ,prolongation of peak latencies or interpeak intervals of ABR occurred in 36 .36%(25 .00% ears) autistic children .The ratio of prolongation of peak latencies of I ,III ,V waves and interpeak inter‐vals of I-III ,III-V ,I-V occurred in 4 .54% ,6 .82% ,13 .64% ,18 .18% ,6 .83% and 15 .91% ,respectively . Conclusion The ABR in some autistic children present abnormality and occur in various forms with the prolongation of interpeak intervals of I -III as the most common .