中文摘要：

目的研究高碘及高碘条件下不同硒摄入水平对实验性自身免疫性甲状腺炎（experimental autoimmunethyroiditis,EAT）大鼠肝、脑SOD、GPX活性的影响。方法选择易感Lewis大鼠建立EAT模型,将动物随机分为5组,即对照组（C组）、模型组（M组）、造模＋高碘高硒组（M＋I＋Se＋组）、造模＋高碘适硒组（M＋I＋Se组）、造模＋高碘低硒组（M＋I＋Se-组）。按照实验设计对各组动物喂以不同硒、碘水平饲料。16周后,对大鼠的甲状腺组织进行病理学检查,测定甲状腺自身抗体（TGAb、TMAb）及大鼠肝、脑组织SOD、GPX活性。结果光镜下观察,M组大鼠甲状腺组织出现散在淋巴细胞浸润;M＋I＋Se＋组及M＋I＋Se组部分小叶受累,有淋巴细胞浸润;M＋I＋Se-组病变严重,几乎所有小叶受累。与C组相比,M组大鼠甲状腺自身抗体（TGAb、TMAb）水平明显升高,肝脏GPX活性显著降低。M＋I＋Se组与M组相比,脑组织GPX活性显著降低。与M＋I＋Se-组相比,M＋I＋Se＋组肝、脑GPX活性显著升高,M＋I＋Se组肝脏GPX活性显著升高。肝、脑GPX及SOD活性均有随硒摄入量增加而增强的趋势。结论EAT时大鼠机体抗氧化能力下降,高碘及低硒均可加重EAT大鼠甲状腺、肝、脑组织的氧化损伤,补硒可以提高组织GPX活性。

英文摘要：

Objective To research the effects on the activities of SOD, GPX in EAT rats＇liver and brain at the high iodine and various selenium supplement. Methods Choose sensitive Lewis rats to make Experimental Autoimmune Thyroiditis （EAT） model. They were divided into 5 gruops randomly, C group, M group, M ＋ I ＋ Se^＋ group, M ＋ I ＋ Se group, M ＋ I ^＋ Segroup. According to the experimental design, the rats were given different water and forage with different iodine and selenium level. Observing the pathological change of the tissue of thyroid glands, determining the autoantibody （TGAb, TMAb）, the activity of SOD, GPX in rats＇liver and brain after 16 weks. Results The lymphocytes infiltrated can be seen under light microscope in M group. Some of thyroid folials were destroyed in M ＋ I^ ＋ Se^＋ group. Thyroids of rats in M ＋ I ^＋ Se group pathological changed lightly. Nearly all of thyroid folials were destroyed in M ＋ I^ ＋ Se - group. Compaired with C group, the thyroid autoantibody （TGAb, TMAb） advanced significantly, but the liver GPX degraded significantlyin M group. The activity of GPX in M ＋ I^＋ Se group rats＇ brains was lower than M group＇s. Compaired with M ＋ I^＋ Se group, the activity of GPX degraded significantly in M ＋ I ^＋ Segroup rats＇livers. Conclusions EAT could destroy the rats＇thyroids and breakdown the antioxygen ability, and high iodine with low selenium intaking could aggravate these effects. Selenium supplement could raise tissues＇s GPX activity.